The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 1982
Filed:
Sep. 11, 1980
Applicant:
Inventors:
Shigeshi Toyoshima, Tokyo, JP;
Ryuichi Sato, Gunma, JP;
Koichi Ito, Higashi-Kurume, JP;
Toshio Shinohara, Annaka, JP;
Yasushi Yamamoto, Takasaki, JP;
Assignee:
Shin-Etsu Chemical Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F / ; A61K / ;
U.S. Cl.
CPC ...
548110 ; 424184 ;
Abstract
The invention provides a novel compound 2-(3-trimethylsilylpropyl)benzothiazole having remarkable anti-tumor effects or, in particular, inhibiting growth of melanoma cells in test animals. The compound is synthesized by the ring-closing intramolecular dehydration condensation of 2-mercapto-(.gamma.-trimethylsilyl)butyroanilide which in turn is obtained by the dehydrochlorination condensation of 2-aminothiophenol and .gamma.-trimethylsilylbutyryl chloride in a polar solvent in the presence of an acid acceptor.