The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 1982
Filed:
Aug. 01, 1980
Tobias O Yellin, Wallingford, PA (US);
Derrick M Mant, Bramhall, GB;
Imperial Chemical Industries Limited, London, GB;
ICI Americas Inc., Wilmington, DE (US);
Abstract
The invention relates to oxadiazole derivatives which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture and to pharmaceutical compositions containing them. The oxadiazole derivatives are of the formula: ##STR1## in which Y is O, S, CH.sub.2 or a direct bond; m is 0 to 4 and n is 1 to 4, provided than when Y is S or O m is 1 to 4 and when Y is O n is 2 to 4; A is a 3,4-dioxocyclobuten-1,2-diyl radical or C.dbd.Z in which Z is O, S, NCN, NNO.sub.2, CHNO.sub.2, NCONH.sub.2, C(CN).sub.2, NCOR.sup.1, NCO.sub.2 R.sup.1, NSO.sub.2 R.sup.1 or NR.sup.2 in which R.sup.1 is alkyl or aryl and R.sup.2 is H or alkyl; B is alkoxy or alkylthio or NHR.sup.3 in which R.sup.3 is H or alkyl: and the salts thereof.