The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 1982
Filed:
Oct. 20, 1975
Applicant:
Inventors:
Klaus Bonhard, Hanau, DE;
Uwe Boysen, Frankfurt, DE;
Assignee:
Biotest-Serum-Institut GmbH, Frankfurt am Main, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07G / ; C07C / ; A61K / ;
U.S. Cl.
CPC ...
424101 ; 2601 / ; 2601 / ; 424177 ;
Abstract
Hemoglobin molecules are coupled so as to increase their intravascular residence times without significantly diminishing their oxygen transport ability. This is achieved by coupling hemoglobin molecules to one another and/or to serum proteins and gelatin derivatives using dialdehydes such as aliphatic dialdehydes of 3 to 8 carbon atoms, optionally followed by addition of pyridoxal phosphate. The desired material isolated by ammonium sulfate precipitation, the sulfate being added before, simultaneously with, or after the dialdehyde. Solution of the precipitate followed by dialysis and/or ion exchange can also be undertaken.