The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 1982
Filed:
Aug. 15, 1980
Applicant:
Inventors:
Otto Grawinger, Frankfurt am Main, DE;
Thomas Raabe, Rodenbach, DE;
Rudi Beyerle, Frankfurt am Main, DE;
Josef Scholtholt, Hanau-Mittelbuchen, DE;
Rolf-Eberhard Nitz, Frankfurt am Main, DE;
Assignee:
Cassella Aktiengesellschaft, Frankfurt am Main, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
424246 ; 42424851 ; 42424854 ; 424250 ; 424258 ; 544128 ; 544 586 ; 544363 ; 546165 ;
Abstract
A 1-acyl-8-[2,3-epoxypropoxy]- and/or 1-acyl-8-[3-halo-2-hydroxypropoxy]-1,2,3,4-tetrahydroquinoline are reacted with primary and secondary amines to obtain corresponding physiologically-active 1-acyl-8-[3-amino-2-hydroxypropoxy]-1,2,3,4-tetrahydroquinolines and pharmacologically-acceptable acid-addition salts thereof. These compounds are useful as such or in conventional medicament compositions for treating those afflicted with heart ailments and/or hypertension.