The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 1982
Filed:
Oct. 01, 1980
Applicant:
Inventors:
Karel Wiesner, Fredericton, CA;
Rinaldo Marini-Bettolo, Fredericton, CA;
Connie S Tsai, Fredericton, CA;
Thomas Y Tsai, Fredericton, CA;
Assignee:
Advance Biofactures Corporation, Lynbrook, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J / ;
U.S. Cl.
CPC ...
536-5 ; 26023957 ; 2602 / ; 549214 ; 549479 ;
Abstract
A method for synthesizing a cardenolide or isocardenolide by subjecting an .alpha.,.beta.-unsaturated steroidal 17-ketone to a double bond shift and hydrogenation to produce a (C/D cisoid) ketone which is treated with an organometallic reagent to yield a tertiary alcohol and the acidifying said alcohol to produce said cardenolide or isocardenolide is shown. The invention also relates to organometallic reagents particularly useful in such method.