The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 1981
Filed:
Sep. 20, 1979
Stuart B Laing, Harrow, GB;
Gordon G Weingarten, London, GB;
Glaxo Group Limited, London, GB;
Abstract
A process for the preparation of cephalosporins having a phosphonocarbamoyloxymethyl group at the 3-position by reacting a cephalosporin having at the 3-position a group ##STR1## (wherein R.sup.4 and R.sup.5 are independently alkyl, aralkyl, alicyclic or aryl groups or together form a divalent group) with a compound of formula ##STR2## (wherein R.sup.6, R.sup.7 and R.sup.8 are independently alkyl, aralkyl, alicyclic or aryl groups or any two of R.sup.6, R.sup.7 and R.sup.8 together form a divalent group, and X is halogen) followed by hydrolysis. The 3-phosphonocarbamoyloxymethyl cephalosporin products of the process exhibit antibiotic activity, and if desired may be readily converted to 3-carbamoyloxymethyl cephalosporins which themselves show antibiotic activity.