The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 1981
Filed:
Apr. 01, 1980
Kiyotaka Oyama, Shin-nanyo, JP;
Shigeaki Nishimura, Kudamatsu, JP;
Yuji Nonaka, Shin-nanyo, JP;
Tsutomu Hashimoto, Tokuyama, JP;
Keiichi Kihara, Tokuyama, JP;
Sagami Chemical Research Center, Tokyo, JP;
Ajinomoto Co., Inc., Tokyo, JP;
Toyo Soda Mfg. Co., Ltd., Yamaguchi, JP;
Abstract
An improvement in a method for manufacturing dipeptides from an N-substituted aspartic acid and a phenylalanine lower alkyl ester. The two starting materials are allowed to react with each other in the presence of an immobilized metallo-proteinase in an organic solvent immiscible with water. The enzyme can be recovered for reuse thereof. The loss of materials due to the hydrolysis of the phenylalanine lower alkyl ester is reduced, so that use of the phenylalanine lower alkyl ester in a nearly stoichiometric quantity suffices for the reaction to ensure an improved yield and reduction in cost of industrial production.