The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 1981
Filed:
Aug. 06, 1979
Applicant:
Inventors:
Charles R West, East Amherst, NY (US);
Chung I Hong, Williamsville, NY (US);
Assignee:
Research Corporation, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J / ;
U.S. Cl.
CPC ...
424182 ; 536-5 ; 536-6 ; 536-7 ;
Abstract
Nucleotides of nucleosides or bases having known cytotoxic activity are reacted with steroids, preferably corticosteroids, to form corresponding cytotoxic nucleoside-corticosteroid phosphodiester analogues of the formula: ##STR1## wherein: steroid is the residue formed by removal of a hydroxyl hydrogen atom from a natural or synthetic adrenal corticosteroid containing the characteristic cyclopentanophenanthrene nucleus which is esterified to the phosphate moiety at the 21-position;