The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 21, 1981

Filed:

Jun. 06, 1980
Applicant:
Inventors:

Michael Martin-Smith, Hertford, GB;

Barry J Price, Hertford, GB;

John Bradshaw, Ware, GB;

John W Clitherow, Sawbridgeworth, GB;

Assignee:

Glaxo Group Limited, London, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
424251 ; 548186 ; 548189 ; 26032635 ; 548214 ; 548336 ; 26032636 ; 548337 ; 548342 ; 2603264 ; 549 60 ; 549 74 ; 2603 / ; 549 75 ; 549 76 ; 2603 / ; 549 77 ; 564 27 ; 26032682 ; 564 47 ; 564 56 ; 26032684 ; 564 85 ; 564 86 ; 26032685 ; 564104 ; 564237 ; 26032686 ; 564340 ; 564341 ; 2603472 ; 564346 ; 564353 ; 2603473 ; 564356 ; 564367 ; 2603477 ; 424267 ; 424270 ; 424272 ; 4242 / ; 424275 ; 424285 ; 424321 ; 424322 ; 424326 ; 424330 ; 544242 ; 544335 ; 546186 ; 546194 ; 546209 ; 546210 ; 546213 ; 546214 ; 546281 ; 548146 ;
Abstract

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, N-oxides, hydrates and bioprecursors thereof, in which Y represents .dbd.O, .dbd.S, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 represents hydrogen, nitro, cyano, lower alkyl, aryl, lower alkylsulphonyl or arylsulphonyl; R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen lower alkyl, cycloalkyl, lower alkenyl, aralkyl, hydroxy, lower trifluoroalkyl, lower alkyl substituted by hydroxy, lower alkoxy, amine, lower alkylamino or dialkylamino, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring which may contain other heteroatoms or the group ##STR2## where R.sub.4 represents hydrogen or lower alkyl;


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