The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 1981
Filed:
Sep. 24, 1979
Applicant:
Inventor:
Jacob A Zupan, Lawrence, KS (US);
Assignee:
INTERx Research Corporation, Lawrence, KS (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07C / ;
U.S. Cl.
CPC ...
560 29 ; 560-1 ; 560 27 ; 560 28 ; 560 49 ; 560 55 ; 560 61 ; 560 65 ; 560 73 ; 560100 ; 560107 ; 560121 ; 560122 ; 560123 ; 560124 ; 560138 ; 560142 ; 560105 ; 560106 ; 560108 ; 560109 ; 2603437 ; 260404 ; 2604055 ; 2604 / ; 2604 / ; 26050117 ; 26050118 ; 424314 ; 424316 ; 424263 ; 546256 ; 546263 ; 424280 ; 546283 ; 546314 ; 424308 ; 546318 ; 546322 ; 424311 ; 546326 ; 560 63 ; 424312 ;
Abstract
The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protected aromatic amine; and removing the N-protecting group therefrom.