The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 07, 1981

Filed:

Jan. 14, 1980
Applicant:
Inventors:

James Cairns, Cumbernauld, GB;

Robert T Logan, Lanark, GB;

George McGarry, Airdrie, GB;

Robert G Roy, Larkhall, GB;

Gilbert F Woods, Glasgow, GB;

Assignee:

Akzo N.V., Arnhem, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07J / ;
U.S. Cl.
CPC ...
424243 ; 26039745 ; 2602 / ; 2603974 ;
Abstract

The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## wherein R.sub.1 =alkyl (1-4 C); R.sub.2 =carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same. The novel compounds possess strong anti-inflammatory properties, when applied locally and cause little or systemic, thymolytic, adrenolytic and salt-retaining effects.


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