The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 1981
Filed:
Jun. 29, 1979
Applicant:
Inventor:
Robert Hafeli, Zurich, CH;
Assignee:
Alpha Patent Limited, Tel-Aviv, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ;
U.S. Cl.
CPC ...
435215 ; 435815 ;
Abstract
There is provided a process for the production of pure, concentrated urokinase starting from a crude urokinase solution. The crude urokinase solution is contacted in a medium having a pH of .gtoreq.6 with a porous solid matrix having a high specific surface area on whose surface there is immobilized aprotinin. Subsequently the urokinase adsorbed in this manner is eluted in an elution agent having a pH.ltoreq.4.5. There are obtained highly concentrated and very pure solutions of urokinase. The urokinase is used in medicine as a pharmaceutical for the dissolving of fibrinous clots and coagulums.