The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 1981
Filed:
May. 07, 1979
Edward D Brown, Knutsford, GB;
Imperial Chemical Industries Limited, London, GB;
Abstract
The invention concerns new analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives of the formula: ##STR1## in which R.sup.1 is an optionally substituted phenyl, phenyl- (1-4C)alkyl, naphthyl, monocyclic or bicyclic heteroaromatic or (monocyclic or bicyclic heteroaromatic)- (1-4C)alkyl radical, R.sup.2 is a (3-8C)cycloalkyl, [(3-8C)cycloalkyl]-(1-4C)alkyl or (3-6C)alkenyl radical, or an optionally substituted phenyl or phenyl- (1-4C)alkyl radical, and R.sup.3 is a (1-4C)alkyl radical, preferably a methyl radical; together with pharmaceutically acceptable salts thereof. Also provided are processes for the manufacture of, and pharmaceutical compositions of, derivatives of formula I and salts thereof. Some of the derivatives of formula I possess anti-inflammatory properties and/or are inhibitors of the enzyme prostaglandin synthetase in addition to possessing analgesic properties. A typical compound of the invention is 3-(thien-2-yl)-6-[(N-acetyl)isobutylamino]tetrahydro-1,3,5-triazine-2,4-di one.