The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 1980
Filed:
Apr. 06, 1979
Albert Szent-Gyorgyi, Woods Hole, MA (US);
Gabor B Fodor, Morgantown, WV (US);
National Foundation for Cancer Research, Bethesda, MD (US);
Abstract
Novel chemical compounds of the general formulae: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl, cycloalkyl, aryl or arylalkyl, wherein R.sub.3 through R.sub.10 are hydrogen, alkyl, or aryl, wherein R.sub.5 and R.sub.6 together may form .dbd.0, and wherein X is hydroxy. The compounds are prepared by mixing specified amounts of a dialdehyde, .alpha.-keto-aldehyde, or diketone, such as methylglyoxal or a related compound, and an enediol, such as L-ascorbic acid or a compound that can be converted into an enediol, such as an acyloin, and allowing same to react under a nitrogen atmosphere in the presence of a non-interfering solvent. Compositions containing these novel compounds exhibit cytostatic, hypotensive and analgesic properties and are useful in the treatment of cancer in animals and humans.