The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 1980
Filed:
Aug. 30, 1979
Thomas R Lewis, Bethlehem, NY (US);
William F Michne, Poestenkill, NY (US);
Sterling Drug Inc., New York, NY (US);
Abstract
3-R.sub.1 -6(eq)-R.sub.4 -7-R.sub.2 '-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 ''-11(ax)-R.sub.3 -11(eq)-[CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.n -(2- and 3-furyl)]-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines, useful as analgesics and narcotic antagonists, are prepared either by heating, with formic acid in an organic solvent or with certain ammonium formates, certain lower-alkyl 1-R.sub.1 -4a.alpha.-R.sub.3 -5.alpha.-R.sub.4 -6-R.sub.2 '-7-R.sub.2 -8-R.sub.2 '-9-R.sub.2 ''-3-[CO(CH.sub.2).sub.n -(2- and 3-furyl)]-1,2,3,4,4 a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3-carboxylates or by reaction of a lower-alkyl .beta.-[3-R.sub.1 -6-(eq)-R.sub.4 -7-R.sub.2 '-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 ''-11(ax)-R.sub.3 -1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate with 2 or 3-furylacetic acid in the presence of a strong base.