The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 1980
Filed:
Jun. 20, 1978
Jaroslav Kalvoda, Binningen, CH;
Ciba-Geigy Corporation, Ardsley, NY (US);
Abstract
The invention relates to the preparation of polyhalogenated pregnane derivatives of the formula ##STR1## wherein X represents fluorine or chlorine and R a free or esterified hydroxyl group or chlorine. The new compounds display a high antiinflammatory activity. No side action on the thymus, the body weight or the adrenals can be detected at the therapeutic dose when the compounds are administered topically. The new compounds are therefore particularly suitable for use as medicaments in dermatology. The new compounds can be prepared according to methods known in the art, e.g. by introducing the chlorine atom in 2-position of corresponding compounds which are non chlorinated in this position, or by the introduction of the halogen atom in 9-position starting from the 9,11.beta.-epoxide or the 9,11-dehydro-compound or by acetonization of the 16,17-dihydroxy group or by replacing a 21-hydroxy group by chlorine.