The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 1980
Filed:
Nov. 30, 1978
Applicant:
Inventors:
William F Michne, Poestenkill, NY (US);
Thomas R Lewis, Bethlehem, NY (US);
Assignee:
Sterling Drug Inc., New York, NY (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
546 97 ; 424267 ; 546 74 ;
Abstract
3-R.sub.1 -7-R.sub.2 '-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 ''-11(ax)-R.sub.3 -6(eq)-R.sub.4 -11(eq)-(CH.sub.2 CH.sub.2 CH.sub.2 R.sub.5)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines, generally useful as morphine-like analgesics and as narcotic antagonists, are prepared by reducing, under Wolff-Kishner reaction conditions, a corresponding 3-R.sub.1 -7-R.sub.2 '-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 ''-11(ax)-R.sub.3 -6(eq)-R.sub.4 -11(eq)-(CH.sub.2 CH.sub.2 COR.sub.5)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and, if desired, cleaving a lower-alkoxy, methoxymethoxy or benzyloxy group to an hydroxy group.