The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 1980
Filed:
Nov. 20, 1978
Michael S Verlander, Del Mar, CA (US);
William D Fuller, Lakeside, CA (US);
Murray Goodman, La Jolla, CA (US);
BioResearch, Inc., Farmingdale, NY (US);
Abstract
In the method for the synthesis of a polypeptide chain on an insoluble solid support wherein an amino acid is introduced into a reactor packed with an insoluble solid support containing substituent groups reactive with said amino acid, coupling said amino acid to said support by condensation reaction with said reactive substituent groups, introducing a second similar or dissimilar amino acid into said reactor and coupling said second amino acid to said first amino acid and repeating the process until the desired polypeptide is obtained, the improvement wherein a high pressure flow system is used and the reaction pressure in said reactor during said synthesis is at least 200 psi up to 10,000 psi or more, in order to obtain rapid reactions and quantitative yields of the desired products.