The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 1980
Filed:
Aug. 31, 1978
Applicant:
Inventor:
Choh H Li, Berkeley, CA (US);
Assignee:
Hoffmann-La Roche, Inc., Nutley, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; A61K / ;
U.S. Cl.
CPC ...
2601 / ; 424177 ;
Abstract
Non-covalent complementation of peptide hormonal fragments produces a recombinant with the hormonal activity of the native hormone. The fragments employed can be natural, synthetic or mixed natural-synthetic origin and can contain less than the total amino acid sequence of the native hormone or fragments derived from related hormones. In a preferred embodiment the human growth hormone (HGH) fragments [Cys(Cam).sup.53 -HGH-(1-134)] and [Cys(Cam).sup.165,182,189 -HGH-(141-191)] undergo non-covalent complementation to yield a recombinant having full growth-promoting and prolactin potency of the native human growth hormone.