The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 1980
Filed:
Jun. 17, 1977
Applicant:
Inventor:
Floyd C McIntire, Waukegan, IL (US);
Assignee:
Abbott Laboratories, North Chicago, IL (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07H / ; C08B / ;
U.S. Cl.
CPC ...
424 92 ; 424 88 ; 424 94 ; 424180 ; 536-1 ; 536 18 ; 536119 ; 2601 / ;
Abstract
A bacterial endotoxin lipopolysaccharide of reduced toxicity covalently coupled to a protein antigen exhibits enhanced adjuvant effects. The coupling was affected by reaction with haloacylhalide. Lipopolysaccharide acylated with an anhydride of a dibasic acid is detoxified; in combination with endotoxin polysaccharide covalently coupled to protein antigen it developed synergistic immunogenic effects.