The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 1980
Filed:
Feb. 01, 1978
William J Asher, Fanwood, NJ (US);
Tina C Vogler, South Orange, NJ (US);
Exxon Research & Engineering Co., Florham Park, NJ (US);
Abstract
The present invention relates to liquid membrane capsules which rupture when contacted with biliary or pancreatic secretions in the intestine thereby releasing their contents in the intestine so the contents become fully available for the treatment of disease at that location in the animal or patient. Particularly, the rupturable liquid membrane capsules containing urease are used for the treatment of chronic uremia. The liquid membrane capsules comprise an internal aqueous phase which contains an oil insoluble medicinal of choice, some complexing agent, dietary supplement or enzyme particularly suited for the intended treatment. This internal aqueous and oil insoluble phase is encapsulated in a nonaqueous external phase comprising a biologically inert oil component, and a material which will complex with the biliary and/or pancreatic secretions in the intestine thereby causing the rupture of the external phase resulting in the release of the internal phase in the intestine. Thus, the internal phase is isolated during passage through the mouth, esophagus, and stomach. On the absence of this isolation the material might be an irritant or be degraded in some of these areas. The invention is further related to a method of in vivo detoxification comprising the use of liquid membrane capsules containing detoxification materials such as medicinals and/or enzymes as an aqueous internal phase encapsulated in a continuous external phase comprising an oil which external phase further contains an additive which complexes with the biliary and/or pancreatic secretions in the intestine causing the rupture of the external phase, the detoxification process proceeding by the rupture of the external phase resulting in the release of the internal phase in the intestine. The internal phase in this case is such that it will bring about a conversion of certain toxins in the intestine to forms that can readily be trapped by conventional toxin trapping LMC as described by prior art.