The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 1979
Filed:
Sep. 28, 1977
Howard H Weetall, Big Flats, NY (US);
Corning Glass Works, Corning, NY (US);
Abstract
This invention relates to means for determining the presence of Neisseria bacteria in a fluid sample, the method generally comprising reacting antibodies with an enzyme released during lysis of the fluid sample, and then testing for inhibition of activity of the enzyme. Inhibition of enzyme activity caused through the contact of antibodies specific to the enzyme can be readily detected. The enzyme released from Neisseria bacteria upon lysis possesses the faculty of oxidizing 1,2-propanediol and reducing nicotinamide-adenine-dinucleotide (NAD). Although the structure and behavior of the enzyme are not comprehended entirely, the above-mentioned faculty of the material has suggested the term 1,2-propanediol dehydrogenase therefor. The specific inventive feature of the instant method is the use of (NH.sub.4).sub.2 SO.sub.4 to precipitate the antigen-antibody complex which thereby concentrates the enzymes and can remove possibly interfering materials.