The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 1979
Filed:
Jun. 14, 1977
Rhone-Poulenc Industries, Paris, FR;
Abstract
Indolizino[7,6,5-de]isoquinoline derivatives of the general formula: ##STR1## wherein the symbol R.sub.1 represents a hydrogen atom, the symbol R.sub.2 represents a hydrogen atom, an amino radical, or a straight- or branched-chain alkyl radical which is optionally substituted on a terminal carbon atom by a vinyl, ethynyl, carboxy, alkoxycarbonyl, cyano, dialkoxymethyl, hydroxymethyl, dialkylaminomethyl (the alkyl radicals of which may form with the nitrogen atom to which they are attached a saturated five- or six-membered heterocyclic ring which may contain another hetero-atom selected from nitrogen, oxygen and sulphur, and -- when a second nitrogen atom is present -- may optionally be N-methylated) or trialkylammoniomethyl radical, or R.sub.2 represents a straight- chain alkyl radical which is substituted on the terminal carbon atom by an aminomethyl, alkylaminomethyl or hydroxyalkylaminomethyl radical, and the symbols R.sub.3 and R.sub.4 together form a valence bond, or the symbols R.sub.1 and R.sub.4 together form a valence bond and the symbols R.sub.2 and R.sub.3 together form a grouping of the general formula: ##STR2## wherein the group --OR.sub.5, which represents an alkoxy radical, is attached to the carbon atom situated in the .alpha.-position to the nitrogen atom carrying R.sub.3, the alkyl and alkoxy radicals, or moieties of groups, within the definition of symbols R.sub.2 and R.sub.5 containing from 1 to 4 carbon atoms and their salts are active as antimicrobial agents and antifungal agents, and are suitable for use as local antiseptics.