The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 1978
Filed:
May. 23, 1977
Gilbert W Adelstein, Evanston, IL (US);
G.D. Searle & Co., Chicago, IL (US);
Abstract
The present invention encompasses compounds of the formula ##STR1## AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF WHEREIN R represents hydrogen, alkanoyl having 1 to 7 carbon atoms, or lower alkyl having 1 to 7 carbon atoms; X and Y represent alkylene having 1 to 3 carbon atoms and Ar, Ar', and Ar' represent phenyl, halosubstituted phenyl, lower alkyl substituted phenyl wherein the lower alkyl contains 1 to 4 carbon atoms; and Ar'' represents phenyl, pyridyl, lower alkyl substituted phenyl wherein the lower alkyl contains 1 to 4 carbon atoms or halosubstituted phenyl. Compounds of the present invention are prepared by reaction of triarylalkanoyl halide with appropriately substituted piperidine followed by subsequent reduction of the resulting amide. Compounds of the present invention are potent antidiarrheal compounds with unexpected separation of antidiarrheal and central nervous system properties.