The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 1978
Filed:
Mar. 10, 1977
Applicant:
Inventors:
Assignee:
Societa' Farmaceutici Italia S.p.A., Milan, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07H / ;
U.S. Cl.
CPC ...
424180 ; 536-4 ; 536 17 ; 536121 ;
Abstract
Doxorubicin thioesters of the formula ##STR1## wherein R is acyl and which are useful in treating animal tumors, are prepared by reacting 14-bromo-daunomycin with a salt of a thioacid of the formula RSM wherein R is as defined above and M is an alkali metal atom or a quaternary ammonium salt in an inert polar solvent. The invention described herein was made in the course of work under a grant from the Department of Health, Education, and Welfare.