The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 1978
Filed:
Jun. 17, 1976
Enrico Sianesi, Milan, IT;
Giuseppe Bonola, San Donato Milan, IT;
Ivo Setnikar, Milan, IT;
Maria Jose Magistretti, Milan, IT;
Recordati S.A. Chemical and Pharmaceutical Company, Chiasso, CH;
Abstract
Therapeutically active 2- and 3-substituted benzoic acid derivatives having the general formula ##STR1## wherein X is OH, NH.sub.2 or an anilino group having the phenyl ring unsubstituted or substituted by chlorine or by a 4-ethoxy group; or ##STR2## wherein X is NH.sub.2 or an anilino group having the phenyl ring unsubstituted or substituted by chlorine or by a 4-ethoxy group; pharmacologically acceptable mineral or organic acid addition salts including quaternary ammonium salts of those compounds having a basic nitrogen atom and alkaline or alkaline earth metal salts of those compounds wherein X is OH. Compounds of the formula wherein X is amino or anilino are prepared by reacting 3-propionylsalicyclic acid or a functional derivative thereof with ammonia or an amine in an anhydrous solvent. Compounds of the formula wherein X is OH are prepared by etherifying the ethylester of 3-propionylsalicyclic acid with diethylaminoethylchloride in the presence of an acid binding agent in a ketonic solvent and thereafter hydrolyzing the ester group with a mineral acid or an alkaline earth metal hydroxide.