The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 23, 1978

Filed:

Jul. 26, 1976
Applicant:
Inventors:

Lucien Nedelec, Le Raincy, FR;

Andre Pierdet, Noisy-le-Sec, FR;

Claude Dumont, Nogent-sur-Marne, FR;

Marie-Helene Kannengiesser, Paris, FR;

Assignee:

Roussel Uclaf, Paris, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07C / ;
U.S. Cl.
CPC ...
424330 ; 544398 ; 544403 ; 544401 ; 26029372 ; 26032681 ; 2605 / ; 2605 / ; 42424858 ; 424250 ; 4242484 ; 424267 ; 424274 ; 544174 ; 544178 ;
Abstract

Novel 7-amino-benzocycloheptenes of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, bromine and iodine in the 2- or 4-position when a halogen, Y and Z are hydrogen or together form a double bond, R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and phenyl optionally substituted with fluorine, chlorine, methyl or methoxy, R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R.sub.2 is selected from the group consisting of alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are attached form a saturated heterocycle of 4 to 6 carbon atoms and optionally containing another hetero-atom and optionally substituted with an alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive activity and their preparation and novel intermediates.


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