The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 1978
Filed:
Mar. 19, 1976
Applicant:
Inventors:
Hendricus Bernardus Welle, Utrecht, NL;
Volkert Claassen, Weesp, NL;
Assignee:
U.S. Philips Corporation, New York, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
424304 ; 2604 / ; 26050117 ; 2605 / ; 424316 ; 424327 ;
Abstract
The compounds of the formula ##STR1## where Hal is Br or Cl and R is ethoxy, methoxymethyl, ethoxymethyl, cyano, methoxyethoxy or cyanomethyl when Hal is Cl and is cyano, methoxy or methoxyethoxy when Hal is Br and their salts have a strong anti-depressive activity resulting in a powerful potentiation of noradrenalin and in a strong serotonin potentiation. Monoamino oxidase inhibition does not provide a basis for the antidepressive activity of these compounds. The compounds are free from noxious side effects to a considerable extent, for example, broncho-constriction and stomach ulceration.