The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 4072683 B1

Date of Patent:

Feb. 07, 1978

Filed:

Nov. 10, 1975

3,4-dihydrocarbostyril derivatives

Applicant:

Inventors:

Kazuyuki Nakagawa, Tokushima, JA;

Minoru Uchida, Komatsushima, JA;

Hiroaki Oka, Tokushima, JA;

Assignee:

Otsuka Pharmaceutical Co., Ltd., Tokyo, JA;

Attorney:

Primary Examiner:

Alton D Rollins

Assistant Examiner:

Mary Vaughn

Int. Cl.

CPC ...

C07D / ; C07D / ; A61K / ;

U.S. Cl.

CPC ...

2602 / ; 2602 / ; 2602 / ; 424258 ;

Abstract

Novel (3'-alkylamino-2'-hydroxy)propoxy-3,4-dihydrocarbostyril derivatives having .beta.-adrenergic nerves blocking activity and hypotensive activity and useful as a remedy for angina pectoris, irregular pulse and hypertension, etc., represented by the formula, ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl or aralkyl and R.sub.2 is C.sub.1 -C.sub.4 alkyl, are prepared by reacting a 3,4-dihydrocarbostyril derivative represented by the formula, ##STR2## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl or aralkyl, with an epihalogenohydrin represented by the formula, ##STR3## wherein X is halogen, reacting the resulting product with an alkylamine represented by the formula,

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