The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 1977
Filed:
Jan. 23, 1976
Applicant:
Inventors:
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
2605 / ; 2603403 ; 2603 / ; 2603406 ; 2603 / ; 2603 / ; 2603 / ; 2603 / ; 2603473 ; 2603474 ; 2603477 ; 2603478 ; 2604 / ; 2604 / ; 2604 / ; 2604 / ; 260469 ; 2604 / ; 2604 / ; 2604 / ; 2604 / ; 2604 / ; 2605 / ; 2605 / ; 2605 / ; 260571 ; 260578 ;
Abstract
A process for the preparation of 9,10-seco-steroids of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, amino, OR.sup.5, OCOR.sup.6 or NHCOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl or phenyl; R.sup.3 is lower alkyl; R.sup.4 is oxo, ##STR2## wherein R.sup.13 is lower alkyl, lower alkoxy - lower alkylene, tetrahydropyranyl or tetrahydrofuryl, R.sup.14 is lower alkyl or aryl and R.sup.15 and R.sup.16 are lower alkyl or taken together form lower alkylene or arylene, and n is 1 or 2 is disclosed. The 9,10-seco-steroids of this invention are useful intermediates for the preparation of steroids.