The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 1977
Filed:
Apr. 14, 1976
Applicant:
Inventors:
Arthur Martin Felix, West Caldwell, NJ (US);
Arnold Alvin Liebman, Upper Saddle River, NJ (US);
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ;
U.S. Cl.
CPC ...
2601 / ; 2603262 ; 2605342 ;
Abstract
Radiolabelled and isotopically labelled peptides are prepared in a convenient and efficient manner by catalytically tritiating or deuterating an analog of the desired peptide containing one or more amino acid residues having an ethylenic type unsaturated bond therein. Preferred amino acid residues for this purpose include 3,4-dehydroproline (.DELTA..sup.3 -proline) and trans-4,5-dehydrolysine (.DELTA..sup.4 -lysine).