The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 1977
Filed:
Jul. 18, 1975
Shigeharo Inouye, Yokohama, JA;
Shoji Omoto, Tokyo, JA;
Katsuyoshi Iwamatsu, Ayase, JA;
Takashi Tsuruoka, Kawasaki, JA;
Taro Niida, Yokohama, JA;
Toyoaki Kawasaki, Tokyo, JA;
Meiji Seika Kaisha, Ltd., Tokyo, JA;
Abstract
As new compounds are provided 9,3',4'-trialkanoyl SF-837 M.sub.1 substances which have therapeutically useful antibacterial activity and do not show any objectionable long-lasting bitter taste upon its oral administration. These 9,3',4'-trialkanoyl SF-837 M.sub.1 substances may be prepared from SF-837 substance, 9,2',3'-tri-acetyl SF-837 M.sub.1 substance, 9,2'-di-acetyl SF-837 substance, 9-propionyl SF-837 substance or 9,2'-dipropionyl SF-837 substance by acylating the latter with an alkanoic acid anhydride at 50.degree.-120.degree. C to produce the corresponding 9,2',3',4'-tetra-alkanoyl SF-837 M.sub.1 substance and occasionally the 9,18,2',3',4'-penta-alkanoyl SF-837 M.sub.1 substance, with involving the shift of the 4'-alkanoyl group to the 3'-hydroxyl group. Partial and selective hydrolysis of the 9,2',3',4'-tetra-alkanoyl SF-837 M.sub.1 substance and/or the 9,18,2',3',4'-penta-alkanoyl SF-837 M.sub.1 substance so produced gives the desired 9,3',4'-tri-alkanoyl SF-837 M.sub.1 substance.