The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 1977
Filed:
Dec. 16, 1974
Allan M Green, Gates Mill, OH (US);
Other;
Abstract
A composition to be used in a method for imaging liver and for biliary function, the composition comprising a scanning agent that is combined with a radioisotope. The scanning agent is preferably a glycoprotein whose glycosidic side chains terminate in a sialic acid moiety followed by a galactose as exemplified by gamma globulin. The preferred radioisotope is technetium (.sup.99m Tc). The composition of the invention will bind to hepatocyte (liver cell) membranes whereas most known pertechnetated hepatic scanning agents attach to the reticuloendothelial cells of the liver (Kuppfer cells) with the advantage being that the present composition will be excreted into the bile ducts and make its way to the intestines, thus acting as an indicator of biliary tree patency. The composition has been administered to human subjects and animals for liver imaging using the anger camera as well as for evaluating the biliary function.