The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 1976
Filed:
Nov. 22, 1974
Nicolae S Bodor, Lawrence, KS (US);
Kenneth B Sloan, Lawrence, KS (US);
Yu-Neng Kuo, Lawrence, KS (US);
Interx Research Corporation, Lawrence, KS (US);
Abstract
There is provided, a method for synthesizing certain selected pro-drug forms of theophylline, having the formula: ##STR1## wherein R represents a member selected from the group consisting of a straight or branched C.sub.4 -C.sub.20 alkyl group, a straight or branched C.sub.4 -C.sub.20 alkenyl group, a substituted phenyl group or a substituted or unsubstituted naphthyl group whose substituents are selected from the group consisting of a hydroxy group, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 acyloxy group, and a halogen atom and a substituted or unsubstituted heteroaromatic group whose substituents are selected from the group consisting of a hydroxy group, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 acyloxy group, and a halogen atom, and wherein A represents a member selected from the group consisting of a --CO-- group, a --CO--(CH.sub.2).sub.n --CO-- group, wherein n represents an integer of from 1 to 16, a --CO--CH=CH--CO-- group (cis or trans) a ##STR2## group and a ##STR3## group, which comprises: Reacting theophylline with an appropriate acid in the presence of dimethylformamide, COCl.sub.2 or SOCl.sub.2, organic tertiary or aromatic amine base or inert carrier gas for removing HCl, and suitable solvent. The compounds prepared by this process are useful for treating asthma by releasing theophylline in sustained manner.