The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 1976
Filed:
Jul. 01, 1974
Arkady Mikhailovich Likhosherstov, Moscow, S;
Liya Semenovna Nazarova, Moscow, S;
Alexandr Petrovich Skoldinov, Moscow, S;
Galina Alexandrovna Markova, Moscow, S;
Natalya Veniaminovna Kaverina, Moscow, S;
Other;
Abstract
10'-[.omega.-N-/1,4-diazabicyclo (4,m,O)-alkanyl/-acyl]-Phenothiazines having the formula: ##STR1## wherein X=H, Cl, or CF.sub.3 ; n = 1, 2 or 3; and m = 3 or 5; and their pharmaceutically acceptable acidic addition and quaternary salts are pharmacologically active. The most active compound 10'[.beta.N-/1,4-diazabicyclo-(4,3,0)-nonanyl/-propionyl]-2'-chlorophenoth iazine of the formula: ##STR2## is useful as the active ingredient of a medicated compound possessing spasmolytic and coronary-dilatant effect. The process for producing said compounds comprises reacting an .omega.-chloracyl -2-substituted phenothiazine with a 1, 4-diazabicyclo-(4,m,O)-alaken in an inert solvent medium at a temperature of 50.degree.-140.degree. C followed by isolation of the desired product.