The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 1976
Filed:
Mar. 03, 1972
John G Moffatt, Los Altos, CA (US);
Syntex (U.S.A.) Inc., Palo Alto, CA (US);
Abstract
3'-O-Acyl- and 3-'-O-acyl-5-'-O-acyl- derivatives of 1-(.beta.-D-arabinofuranosyl)-cytosines and methods of preparing these compounds and also O.sup.2,2'-anhydro-1-(3'-O-acyl-5'-O-acyl-.beta.-D-arabinofuranosyl)-cytos ine salts. The O.sup.2,2'-anhydro-1-(3'-O-acyl-5'-O-acyl-.beta.-D-arabinofuranosyl)-cytos ine nucleoside salts are prepared by direct acid catalyzed acylation of the salts of the corresponding O.sup.2,2'-anhydro-1-(.beta.-D-arabinofuranosyl)-cytosines or 3'-O-acyl- derivatives, under carefully controlled conditions. The 3'-O-acyl- and 3'-O-acyl-5'-O-acyl-1-(.beta.-D-arabinofuranosyl)-cytosines are prepared from the corresponding O.sup.2,2'-anhydro nucleosides via selective cleavage of the O.sup.2,2'-anhydro bridge under carefully controlled conditions. The compounds exhibit anti-viral, cytotoxic and anti-neoplastic activity, and thus are useful for the treatment of mammals where such agents are indicated.