The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 1976
Filed:
May. 27, 1975
John R Waters, Towson, MD (US);
Johnston Laboratories, Inc., Cockeysville, MD (US);
Abstract
A method for characterization of biological activity comprising providing a plurality of gas-tight cells each having a light-permeable wall section, each cell containing a different .sup.14 C-labeled fermentable substrate, a carbon dioxide absorber and a scintillation compound in intimate proximity to each other remote from said substrate, and an axenic sample of a biologically active material; subjecting said cells to conditions conducive to biological activity and thereafter measuring the light emitted by the scintillation compound as a result of the decay of .sup.14 CO.sub.2 generated by the metabolic action of the biologically active agent in said sample on said substrate and captured by the carbon dioxide absorber. Apparatus is provided comprising a plurality of sterile chambers containing different .sup.14 C-labeled fermentable substrates, means to facilitate introduction of an axenic sample of a biologically active agent into each chamber, means for sealing each chamber to form a gas-tight cell having a light-permeable wall section, and a carbon dioxide absorber and a scintillation compound in intimate proximity to each other in each cell adjacent the light-permeable wall section.