The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 1976
Filed:
Jan. 29, 1975
William John Welstead, Jr, Richmond, VA (US);
Henry Wayne Moran, Richmond, VA (US);
A. H. Robins Company, Incorporated, Richmond, VA (US);
Abstract
Novel 4-(5- and 7-)benzoylindolin-2-ones of the formula: ##SPC1## Wherein R is hydrogen, lower-alkyl, or methylthio, R.sup.1 is hydrogen or lower-alkyl, R.sup.2 is lower-alkyl, lower-alkoxy, halogen, nitro or trifluoromethyl, R.sup.3 is hydrogen, halogen or lower-alkoxy, and n is 0, 1 or 2, are prepared by (a) acylation of indolin-2-one to give 5-benzoylindoline-2-one, (b) cyclization of 2-acetamido-3-benzoylphenylacetic acid or ethyl 2-acetamido-3-benzoylphenylacetate to give 7-benzoyindoline-2-one, or (c) by reacting aminobenzophenones with alkyl .alpha.(methylthio)acetates to give alkyl 2-amino-3-(5- or 6-)benzoyl-.alpha.-(methylthio)phenylacetates which are cyclized and demethylthiolated to 4-(5- and 7-)benzoylindolin-2-ones. The novel compounds possess anti-inflammatory activity and are intermediates for the preparation of 2-amino-3-(5- or 6-) benzoylphenylacetic acids which posess anti-inflammatory properties.