The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 1976
Filed:
Oct. 25, 1974
Albert Duncan Cale, Jr, Mechanicsville, VA (US);
Charles Arthur Leonard, Richmond, VA (US);
A. H. Robins Company, Incorporated, Richmond, VA (US);
Abstract
A method is disclosed for controlling emesis utilizing N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides of the formula: ##SPC1## Wherein R is cycloalkyl, phenyl and phenyllower-alkyl; R.sup.1 is hydrogen, lower alkyl of 1 to 8 carbon atoms and phenyl; R.sup.2 is halogen, lower-alkyl, lower-alkoxy, amino, nitro, monoalkylamino, dialkylamino, mercaptomethyl, acetamido, sulfamoyl, cyano, hydroxy, benzyloxy, and trifluoromethyl; X is oxygen and sulfur; n is an integer from zero to three inclusive and pharmaceutically acceptable acid addition salts thereof. The benzamide compounds wherein R is cyclohexyl and R.sup.1 is lower-alkyl are particularly effective as antiemetics and have minimal side effects.