The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 1976
Filed:
Jul. 27, 1971
Rudi Beyerle, Bruchkobel, DT;
Adolf Stachel, deceased, LATE OF, DT;
Ingeburg Lydia Stachel, heiress, Frankfurt am Main-Fechenheim, DT;
Rolf-Eberhard Nitz, Bergen-Enkheim, DT;
Klaus Resag, Frankfurt am Main-Fechenheim, DT;
Eckhard Schraven, Frankfurt am Main-Fechenheim, DT;
Cassella Farbwerke Mainkur Aktiengesellschaft, Frankfurt am Main-Fechenheim, DT;
Abstract
The present invention relates to new coumarin compounds useful as coronary dilators and having the formula ##SPC1## Or the hydrochloric acid addition salts thereof, and to methods of preparing same either by acylating, in the presence of acid-binding agents, if desired, coumarin derivatives having the formula ##SPC2## With acylating agents selected from the group consisting of alkoxybenzoic acid having the formula ##SPC3## And functional derivatives thereof, or by condensing, in the presence of acid-binding agents, if desired, coumarin derivatives having the formula ##SPC4## With an amine having the formula RH, wherein R is piperazino which is free of acyloxy groups and is bound via a nitrogen atom; R.sub.1 is selected from the group consisting of alkyl radicals having 1-4 carbon atoms and phenyl; R.sub.2 is selected from the group consisting of 5,7-, 6,7- and 7,8-positioned alkoxy groups having 1-4 carbon atoms; R.sub.3 is selected from alkoxy groups having 1-4 carbon atoms; R.sub.4 is selected from the group consisting of chlorine and bromine; R' is piperazino which is free of hydroxy groups and is bound via a nitrogen group; and m is selected from the group consisting of 1, 2, and 3.