The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 1976
Filed:
Feb. 16, 1973
Henri Demarne, Herault, FR;
Clin Midy, Paris, FR;
Abstract
Pharmacologically valuable 3-(aminopropyl)-indoles have the general formula ##SPC1## In which R.sub.1 is phenyl, halophenyl, nitrophenyl, aminophenyl, loweralkoxyphenyl or pyridyl, R.sub.2 is hydrogen or methyl, R.sub.3 and R.sub.4 are each hydrogen or lower alkyl or taken together form a polymethylene group which may be interrupted by oxygen so that --NR.sub.3 R.sub.4 is a heteromonocycle having 5 or 6 nuclear atoms and R.sub.5 is hydrogen, fluorine, chlorine or methoxy. Especially interesting are those compounds in which at least one of R.sub.1 and R.sub.5 comprises a flourine atom and --NR.sub.3 R.sub.4 is pyrrolidino. The compounds are made by condensation of correspondingly substituted indolylacetones with amines HNR.sub.3 R.sub.4 in a reducing medium or, in certain cases, by reduction of correspondingly substituted indolylacetoximes with or without subsequent lower alkylation.