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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12790285 B1

PDFFull Text
Date of Patent:
Nov. 10, 2026

Filed:

Nov. 18, 2021

[11c]-labeled acyclic retinoid, central nervous system activator, and production methods for same

Applicant:

National Center for Geriatrics and Gerontology, Obu City, JP;

Inventors:

Masaaki Suzuki, Obu City, JP;

Kengo Ito, Obu City, JP;

Yasuyuki Kimura, Obu City, JP;

Aya Ogata, Obu City, JP;

Hiroshi Ikenuma, Obu City, JP;

Tetsuya Kimura, Obu City, JP;

Nobuyuki Kimura, Obu City, JP;

Hiroko Koyama, Gifu, JP;

Hideki Ishii, Chiba, JP;

Meiei Cho, Chiba, JP;

Kazunori Kawamura, Chiba, JP;

Takafumi Minamimoto, Chiba, JP;

Yuji Nagai, Chiba, JP;

Hiroshi Katsuki, Kumamoto, JP;

Assignee:

NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY, Obu City, JP;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Andrew D Kosar

Assistant Examiner:

Connor K English

Int. Cl.
CPC ...
C07B 59/00 (2006.01); A61K 51/04 (2006.01); A61P 25/00 (2006.01); C07C 57/03 (2006.01);
U.S. Cl.
CPC ...
C07B 59/004 (2013.01); A61K 51/0402 (2013.01); A61P 25/00 (2018.01); C07C 57/03 (2013.01); C07B 2200/05 (2013.01);
Abstract

[Object] Provided are aC-labeled acyclic retinoid that can be synthesized in a short time with a high yield and can be suitably used for PET for elucidating intracerebral kinetics, a PET probe using it, and methods for producing them. [Solution] TheC-labeled acyclic retinoid of the present invention is characterized by being represented by the following chemical formula (a). This compound can be produced by a coupling step of cross-coupling a methyl iodide labelled withC and the following organotin compound (b) (provided that in the formula, Rand Rrepresent alkyl groups which may have a branch) in an aprotic solvent in the presence of a palladium complex, a phosphine ligand, and a cuprous halide.

Find Patent Forward Citations

Quick Actions:

Suzuki, Masaaki. (2026). [11c]-labeled acyclic retinoid, central nervous system activator, and production methods for same (U.S. Patent No. 12790285). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12790285

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