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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12788816 B1

PDFFull Text
Date of Patent:
Nov. 10, 2026

Filed:

Jun. 26, 2020

Chimeric antigen receptor with 4-ibb costimulatory domain

Applicant:

Eutilex Co., Ltd., Seoul, KR;

Inventors:

Byoung S. Kwon, Seoul, KR;

Kwanghee Kim, Seoul, KR;

Jiwon Chung, Seoul, KR;

Young Gyoon Chang, Seoul, KR;

Bo-Rim Yi, Seoul, KR;

Jungyun Lee, Seoul, KR;

Sae Rom Lee, Seoul, KR;

Hyuntae Son, Seoul, KR;

Hye Mi Lee, Seoul, KR;

Eun Hye Yoo, Seoul, KR;

Assignee:

EUTILEX CO., LTD., Seoul, KR;

Attorney:

Wood, Phillips, Katz, Clark & Mortimer

Primary Examiner:

Gregory S Emch

Assistant Examiner:

Kathleen undefined Cunningchen

Int. Cl.
CPC ...
A61K 40/31 (2025.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 40/11 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C12N 5/0783 (2010.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 40/31 (2025.01); A61K 40/11 (2025.01); A61K 40/4211 (2025.01); A61K 40/4261 (2025.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70578 (2013.01); C07K 16/2803 (2013.01); C07K 16/303 (2013.01); C12N 5/0636 (2013.01); C12N 5/0646 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C12N 2740/15043 (2013.01);
Abstract

Provided are CAR-T compositions that are directed to a CAR including (i) an extracellular domain comprising an antigen-binding domain; (ii) a transmembrane domain; and (iii) an intracellular domain comprising a costimulatory endodomain, wherein the costimulatory endodomain comprises an intracellular signaling domain from 4-1BB/CD137 and five additional amino acids. The disclosure also provides vectors, compositions, and methods of treatment using the antigen binding molecules and engineered immune cells comprising the CAR. The CAR compositions provided herein can be used for the treatment of certain cancers.

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Quick Actions:

Kwon, Byoung. (2026). Chimeric antigen receptor with 4-ibb costimulatory domain (U.S. Patent No. 12788816). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12788816

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