The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2026

Filed:

Jan. 10, 2022
Applicants:

Vib Vzw, Ghent, BE;

Vrije Universiteit Brussel, Brussels, BE;

Inventors:

Rouslan Efremov, Ghent, BE;

Stefania Torino, Brussels, BE;

Raf Claessens, Neerijse, BE;

Assignees:

Vrije Universiteit Brussel, Brussels, BE;

VIB VZW, Ghent, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/42 (2006.01); G01N 1/28 (2006.01);
U.S. Cl.
CPC ...
G01N 1/42 (2013.01); G01N 1/2813 (2013.01);
Abstract

The present invention relates to the field of time-resolved protein sampling, more specifically for use in structural biology, even more specifically for structural analysis of proteins by Cryogenic-electron microscopy (Cryo-EM). The invention provides for methods and devices for preparing vitrified samples for transmission electron microscopy at millisecond time-resolution using a microfluidics-based integrated device. More specifically, the sampling means and methods combine fast mixing with a tunable droplet-on-demand generation to control droplet formation, spraying and sampling velocity, resulting in a sampling method requiring very limited protein amounts.


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Efremov, Rouslan. (2026). Means and methods for time-resolved sampling (U.S. Patent No. 12782250). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12782250

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