The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2026

Filed:

Mar. 30, 2022
Applicant:

Modernatx, Inc., Cambridge, MA (US);

Inventors:

Atsushi Endo, Belmont, MA (US);

Gabor Butora, Martinsville, NJ (US);

Thomas Steele, Cambridge, MA (US);

Jennifer Beaudoin, Cambridge, MA (US);

Assignee:

ModernaTX, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07F 9/24 (2006.01); C07H 1/02 (2006.01); C07H 19/167 (2006.01); C07H 19/207 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); C07F 9/2408 (2013.01); C07H 1/02 (2013.01); C07H 19/167 (2013.01); C07H 19/207 (2013.01);
Abstract

Provided herein are methods of making trinucleotides and tetranucleotides for use as 5' mRNA caps. The methods utilize a novel 'top-down' strategy and provide for synthesis of oligonucleotides with higher yields and increased efficiency compared to traditional methods. A key step of the methods disclosed, herein can also be adapted to utilize a “one-pot” approach, resulting in an increase in the yield of the final oligonucleotide product.


Find Patent Forward Citations

Quick Actions:

Endo, Atsushi. (2026). Synthesis of trinucleotide and tetranucleotide caps for mrna production (U.S. Patent No. 12780866). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12780866

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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