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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12780831 B1

PDFFull Text
Date of Patent:
Nov. 03, 2026

Filed:

Nov. 06, 2025

Solid forms of posiphen d-tartrate

Applicant:

Annovis Bio, Inc., Malvern, PA (US);

Inventors:

Maria Maccecchini, Malvern, PA (US);

Michael A. Christie, Phoenixville, PA (US);

Vinu V. Panikkattu, Lafayette, IN (US);

Christopher Scott Seadeek, West Lafayette, IN (US);

Assignee:

ANNOVIS BIO, INC., Malvern, PA (US);

Attorneys:

Duane Morris LLP

Thomas J. Kowalski

Primary Examiner:

Umamaheswari Ramachandran

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/407 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/407 (2013.01);
Abstract

Solid forms of (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate, including crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate (posiphen D-tartrate Form A), crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate dihydrate (posiphen D-tartrate Form B), crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate Form A having the peak of Pattern C (posiphen D-tartrate Form A+Pattern C), and amorphous (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate, are disclosed. Pharmaceutical compositions comprising posiphen D-tartrate Form A, posiphen D-tartrate Form B, posiphen D-tartrate Form A having the peaks of Pattern C, and amorphous posiphen D-tartrate, and methods of treating various conditions by administering these solid forms, are also disclosed.

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Maccecchini, Maria. (2026). Solid forms of posiphen d-tartrate (U.S. Patent No. 12780831). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12780831

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