logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12780820 B1

PDFFull Text
Date of Patent:
Nov. 03, 2026

Filed:

Jul. 22, 2021

3-(1h-imidazol-2-yl)-2,3,8,8a-tetrahydroindolizin-5(1h)-one derivatives useful as factor xia inhibitors

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Guozhang Xu, Spring House, PA (US);

Micheal D. Gaul, Spring House, PA (US);

Tho V. Thieu, Spring House, PA (US);

Jing Zhang, Spring House, PA (US);

Mark Wall, Spring House, PA (US);

Ling Hua Gao, Spring House, PA (US);

Bin Zhu, Spring House, PA (US);

Tianbao Lu, Spring House, PA (US);

Boying Guo, Spring House, PA (US);

Zhijie Liu, Spring House, PA (US);

Ravi Nargund, Spring House, PA (US);

Mark J. Macielag, Spring House, PA (US);

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:
Primary Examiner:

Charanjit Aulakh

Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61P 7/02 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); C07F 9/6561 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 7/02 (2018.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01); C07F 9/6561 (2013.01); C07B 2200/05 (2013.01);
Abstract

The present invention is directed to 3-(1H-imidazol-2-yl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one derivatives, stereoisomers, isotopologues, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.

Find Patent Forward Citations

Quick Actions:

Xu, Guozhang. (2026). 3-(1h-imidazol-2-yl)-2,3,8,8a-tetrahydroindolizin-5(1h)-one derivatives useful as factor xia inhibitors (U.S. Patent No. 12780820). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12780820

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…