The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2026

Filed:

Jan. 12, 2023
Applicant:

Hepagene Therapeutics (Hk) Limited, Hong Kong, CN;

Inventors:

Xiaodong Xu, Hong Kong, CN;

Cheng Mo, Hong Kong, CN;

Shijia Chen, Hong Kong, CN;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 417/12 (2006.01); A61K 31/496 (2006.01); A61P 31/12 (2006.01); C07C 309/04 (2006.01); C07C 309/05 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01); A61K 31/496 (2013.01); C07C 309/04 (2013.01); C07C 309/05 (2013.01);
Abstract

The present technology provides crystalline free base and crystalline hydrochloride, hydrobromide, edisylate, and mesylate salts of (R)-2-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)-2-methylpiperazin-1-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid. The present technology further provides methods for preparing the various forms, compositions containing them, and methods related to modulation of FXR. In particular, the present crystalline compounds and compositions may be used to treat FXR-mediated disorders and conditions, including, e.g., hepatitis B, liver disease, hyperlipidemia, hypercholesteremia, obesity, metabolic syndrome, cardiovascular disease, gastrointestinal disease, and atherosclerosis, and renal disease.


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Xu, Xiaodong. (2026). Solid forms of a benzthiazole-piperazinyl-oxazole compound and methods of use thereof (U.S. Patent No. 12780816). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12780816

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