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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12774279 B1

PDFFull Text
Date of Patent:
Oct. 27, 2026

Filed:

Apr. 28, 2022

Phthalimido cereblon complex binders and transcription factor degraders and methods of use

Applicant:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

Tinghu Zhang, Brookline, MA (US);

Lyn Howard Jones, Winchester, MA (US);

Hu Liu, Newton, MA (US);

Jianwei Che, Sharon, MA (US);

Assignee:

DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);

Attorneys:

ArentFox Schiff LLP

Daniel W. Clarke

Shawn P. Foley

Primary Examiner:

Alicia L Otton

Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61K 31/444 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01);
Abstract

Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that may bind to CRBN complex and cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders characterized or mediated by the presence of a protein, and hence would benefit from degradation of said protein.

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Zhang, Tinghu. (2026). Phthalimido cereblon complex binders and transcription factor degraders and methods of use (U.S. Patent No. 12774279). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12774279

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