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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12767647 B1

PDFFull Text
Date of Patent:
Oct. 20, 2026

Filed:

Sep. 16, 2020

Glue degraders and methods of use thereof

Applicant:

Novartis Ag, Basel, CH;

Inventors:

Rohan Eric John Beckwith, San Diego, CA (US);

Simone Bonazzi, Cambridge, MA (US);

Nicole Buschmann, Basel, CH;

Artiom Cernijenko, Cambridge, MA (US);

Aleem Fazal, Wilmington, MA (US);

Matthew James Hesse, Oakland, CA (US);

Julie Lachal, Bartenheim, FR;

Hasnain Ahmed Malik, Boston, MA (US);

James R. Manning, Emeryville, CA (US);

Pierre Nimsgern, Saint Louis, FR;

Gary O'brien, Maynard, MA (US);

Anna Vulpetti, Basel, CH;

Junping Zhao, Arlington, MA (US);

Assignee:

NOVARTIS AG, Basel, CH;

Attorney:

Emily T. Wu

Primary Examiner:

Clinton A Brooks

Assistant Examiner:

Kendall Nicole Heitmeier

Int. Cl.
CPC ...
C07D 405/04 (2006.01); A61K 31/513 (2006.01); A61P 11/00 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 405/04 (2013.01); A61K 31/513 (2013.01); C07D 401/14 (2013.01); C07D 413/04 (2013.01); C07D 471/04 (2013.01);
Abstract

Described herein are glue degrader compounds comprising pyrimidine-2,4-dione and dihydropyrimidine-2,4-dione, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment or prevention of conditions, diseases, and disorders mediated by various target proteins.

Find Patent Forward Citations

Beckwith, Rohan Eric John. (2026). Glue degraders and methods of use thereof (U.S. Patent No. 12767647). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12767647

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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